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Haddad syndrome

1 OMIM reference -
3 associated genes
19 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 1

Hereditary gingival fibromatosis

4 OMIM references -
1 associated gene
2 signs/symptoms

Haddad syndrome

Hereditary gingival fibromatosis

ASCL1	(UniProt - OMIM)		SOS1	(UniProt - OMIM)
PHOX2B	(UniProt - OMIM)
RET	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	RET	(0.63)	SOS1

Citations in the biomedical literature:

Haddad syndrome		Hereditary gingival fibromatosis
	Synonym(s): - Congenital central alveolar hypoventilation - Hirschsprung disease - Ondine-Hirschsprung disease - Ondine-Hirschsprung syndrome		Synonym(s): - Autosomal dominant gingival fibromatosis - Autosomal dominant gingival hyperplasia - Hereditary gingival hyperplasia

	Classification (Orphanet): - Rare abdominal surgical disease - Rare developmental defect during embryogenesis - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare genetic disease - Rare odontologic disease

	Classification (ICD10): - Diseases of the nervous system -		Classification (ICD10): - Diseases of the digestive system -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: normal Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 4 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Haddad syndrome		Hereditary gingival fibromatosis
	Very frequent - Apnea / sleep apnea - Dolichocolon / megacolon / megadolichocolon / Hirschsprung's disease - Dysautonomia / autonomous nervous sytem anomalies - Failure to thrive / difficulties for feeding in infancy / growth delay - Respiratory distress / dyspnea / respiratory failure / lung volume reduction - Respiratory rhythm disorder - Short stature / dwarfism / nanism - Strabismus / squint Frequent - Death in infancy - Gastroesophageal reflux / pyrosis / esophagitis / hiatal hernia / gastroparesia - Hypotonia - Intellectual deficit / mental / psychomotor retardation / learning disability - Seizures / epilepsy / absences / spasms / status epilepticus Occasional - Fetal immobility / abnormal fetal movements - Neuroblastoma - Oligoamnios - Polyhydramnios - Sensorineural deafness / hearing loss		Very frequent - Thickened / hypertrophic / fibromatous gingivae